Paper Previews https://dailydigest.bio AI-generated science article previews Sat, 28 Feb 2026 04:04:34 +0000 The Missing Form: How a Hidden Protein Reveals the True Face of ADA2 Deficiency https://dailydigest.bio/ada2-deficiency/ https://dailydigest.bio/ada2-deficiency/ The Missing Form: How a Hidden Protein Reveals the True Face of ADA2 Deficiency [The Daily Digest] Breaking the Undruggable: A Small Molecule Rewires Cancer Immunity https://dailydigest.bio/checkpoint-immunotherapy-oral-drug/ https://dailydigest.bio/checkpoint-immunotherapy-oral-drug/ Breaking the Undruggable: A Small Molecule Rewires Cancer Immunity [The Daily Digest, The Aliquot] When Oncogenes Go Dark: How Cancer Silences Its Own Drivers https://dailydigest.bio/ecdna-micronucleation/aliquot/ https://dailydigest.bio/ecdna-micronucleation/aliquot/ A new study reveals that cancer cells harboring extrachromosomal DNA are predisposed to a form of genomic misfiling that paradoxically shuts down the very oncogenes driving their growth.. The mechanism involves damaged DNA, collective mis-segregat... [The Aliquot] The Aged Brain Rewrites Its Own Immune Cells, Study Finds https://dailydigest.bio/gizowski/ https://dailydigest.bio/gizowski/ The Aged Brain Rewrites Its Own Immune Cells, Study Finds [The Daily Digest, The Aliquot] Cancer's Rulebook, Rewritten: A Landmark Framework Gets Its Decade Update https://dailydigest.bio/hallmarks/aliquot/ https://dailydigest.bio/hallmarks/aliquot/ A decade after proposing six core capabilities that define malignancy, Douglas Hanahan and Robert Weinberg have returned with a more complete map of how cancer works — one that adds metabolism, immunity, and the tumor's hidden ecosystem to the equ... [The Aliquot] Cancer's Hidden Shield: How Stressed Tumors Corrupt the Immune System https://dailydigest.bio/isr-lipocalin2/aliquot/ https://dailydigest.bio/isr-lipocalin2/aliquot/ A protein secreted by stressed cancer cells has been caught sabotaging the immune system from within, corrupting the very macrophages that should be sounding the alarm. [The Aliquot] Seeing the Cell, Not the Molecule: How Microscopy Images Are Reshaping Drug Discovery https://dailydigest.bio/jiang/ https://dailydigest.bio/jiang/ For decades, the search for new medicines has begun with a simple assumption: that molecules resembling a known drug will behave like one.. A new study of 112,480 compounds suggests that assumption has been costing us discoveries. [The Daily Digest, The Aliquot] A Repurposed Antipsychotic Silences Seizures in Human Brain Tissue https://dailydigest.bio/kcc2-interictal-epilepsy/aliquot/ https://dailydigest.bio/kcc2-interictal-epilepsy/aliquot/ Surgically removed brain tissue from patients with drug-resistant epilepsy continued to fire in rhythmic, seizure-like bursts in the laboratory dish.. Then researchers added prochlorperazine, a decades-old antinausea drug, and the electrical storm... [The Aliquot] One tiny RNA is breaking immune tolerance — and it targets the estrogen receptor https://dailydigest.bio/microrna-bcell-tolerance/ https://dailydigest.bio/microrna-bcell-tolerance/ One tiny RNA is breaking immune tolerance — and it targets the estrogen receptor [The Daily Digest] Immune Cells Programmed to Attack Mitochondria Trigger Parkinson's Disease in Mice https://dailydigest.bio/mito-antigen-cd8-dopamine/aliquot/ https://dailydigest.bio/mito-antigen-cd8-dopamine/aliquot/ Immune Cells Programmed to Attack Mitochondria Trigger Parkinson's Disease in Mice [The Aliquot] When More Interferon Means Less Immunity: The Metabolic Collapse at the Heart of Severe COVID-19 — The Aliquot · Deep Dive https://dailydigest.bio/multiomics-covid-ifn/ https://dailydigest.bio/multiomics-covid-ifn/ When More Interferon Means Less Immunity: The Metabolic Collapse at the Heart of Severe COVID-19 — The Aliquot · Deep Dive [Deep Dive] Breaking the Undruggable: A Small Molecule Rewires Cancer Immunity https://dailydigest.bio/ptpn/aliquot/ https://dailydigest.bio/ptpn/aliquot/ For decades, protein phosphatases were written off as targets too chemically hostile to drug.. A new compound challenges that verdict, and the results in preclinical cancer models are striking. [The Aliquot] The Lung Has Its Own Tumor Killers. We Just Found the Off Switch. https://dailydigest.bio/ptpn-lung-metastasis/ https://dailydigest.bio/ptpn-lung-metastasis/ The Lung Has Its Own Tumor Killers. We Just Found the Off Switch. [The Daily Digest, Deep Dive] A Stemness Score Tracks Prostate Cancer From Diagnosis to Lethal Disease https://dailydigest.bio/stemness-prostate-cancer/aliquot/ https://dailydigest.bio/stemness-prostate-cancer/aliquot/ A new study spanning 87,000 tumor samples proposes that a single molecular score, measuring how 'stem-like' a cancer cell has become, can track prostate cancer from its earliest stages to its most lethal form and predict which patients will die fr... [The Aliquot] Young Blood Reverses Cognitive Aging in Mice, Pointing to a Molecular Fountain of Youth https://dailydigest.bio/villeda/aliquot/ https://dailydigest.bio/villeda/aliquot/ A series of experiments connecting old mice to young circulatory systems has produced something that aging research rarely delivers: a reversal.. Not a slowing, not a prevention, but a genuine rolling-back of cognitive decline already in progress. [The Aliquot] Seeing the Cell: How Microscopy Images Are Reshaping Drug Discovery at Scale https://dailydigest.bio/wang/ https://dailydigest.bio/wang/ For decades, chemists have searched for new drugs by looking for molecules that resemble ones that already work.. A new study argues that approach is leaving too much on the table, and that the answer lies not in chemical structure, but in what a ... [The Daily Digest, The Aliquot] The Janus Cell: A Peripheral Sentinel That Mirrors the Thymus https://dailydigest.bio/wang-aire/ https://dailydigest.bio/wang-aire/ Deep in the lymph nodes, a newly discovered immune cell quietly patrols for self-reactive T cells that slipped past the thymus.. It borrows its toolkit from two different lineages and, against all expectation, looks almost exactly like the thymic ... [Scrollytelling, The Aliquot] Your Brain Rewrites the Rulebook — and Dopamine Keeps Score https://dailydigest.bio/dopamine-adaptive-learning/ https://dailydigest.bio/dopamine-adaptive-learning/ Your Brain Rewrites the Rulebook — and Dopamine Keeps Score [The Daily Digest]